11 Investor presentation First six months of 2023 SELECT will add to the clinical evid establish obesity as a serious chr Obesity is a global epidemic affecting more than 764 million people 1 Obesity is associated with > 200 possible health complications including cardiovascular disease 2 SELECT adds to c STEP & OA ✓ Demonstrate supe loss with semaglu placebo for peopl obesity Obesity prevalence (%) <10.0 10.0 – 19.9 20.0 – 29.9 ≥30.0 Not applicable STEP HFpE ✓ Demonstrate supe improvement in K placebo 1 World Obesity Atlas 2022 2 Yuen M., Earle R., Kadambi N., et al. A systematic review and evaluation of current evidence reveals 236 Note: Obesity is defined as BMI > 30; PwO: People with obesity; KCCQ-CSS: Kansas City Cardiomyopathy Questionnaire Clinical sum AOM: Anti-obesity medication; CV: Cardiovascular
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